麻豆果冻传媒

Research and Innovation

We inform our care with the following research efforts:

Basic Science and Engineering (BASE) Research Initiative

brings together experts from multiple specialties across the Stanford University campus and its hospitals鈥攊ncluding computational modeling, tissue engineering, genetics, and molecular biology鈥攖o create bold new solutions for children with heart disease.

Cardiovascular Biomechanics Computation Lab

develops fundamental computational methods for the study of cardiovascular disease progression, surgical methods, treatment planning, and medical devices. It focuses on patient-specific modeling in pediatric and congenital heart disease, as well as adult cardiovascular disease. The lab bridges engineering and medicine through the department of Pediatrics, the department of Bioengineering, and the Institute for Computational and Mathematical Engineering. Research related to congenital heart disease includes exploring the ability to grow hypoplastic hearts.

Cardiovascular Engineering Research Lab

The studies congenital heart disease and its surgical therapies. Computational fluid dynamics and ex-vivo biomechanical simulations are utilized to inform experiments and facilitate rapid translation to the operating room for immediate patient benefit. Ongoing collaborations focus on the development of medical devices to accelerate growth in hypoplastic valves and ventricles, as well as in individual patient-tailored planning and design of upcoming heart surgery.

SimVascular Software and Vascular Model Repository

SimVascular open-source software, used by ; the University of California, Berkeley; the National Science Foundation; and other respected institutions, provides a way to capture medical images and patient data to create specific blood flow simulation and analysis models. The software and repository are used to simulate cardiovascular and pulmonary solid and fluid mechanics and to provide spatially and temporally resolved benchmark solutions that are used by academic, government, and industry researchers to verify their computational methods.

Research specific to congenitally corrected transposition of the great arteries (CCTGA)

At 麻豆果冻传媒 Children鈥檚 Health, we鈥檝e been performing research related to CCTGA for nearly two decades. Our researchers study various aspects of the complex care of CCTGA patients, including:

  • Surgical methods.
  • Surgical management and outcomes.
  • Findings from imaging studies and predictors of outcomes.
  • Medical management and outcomes.
  • Biomarkers that may predict the ability of older patients to undergo successful left ventricular training.

Selected Stanford research publications on CCTGA:

  1. .鈥 Ma M, Mainwaring RD, Hanley FL, Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2019;22:51鈥56.
  2. .鈥 Mainwaring RD, Patrick WL, Arunamata A, et al., J Thorac Cardiovasc Surg 2019.
  3. .鈥 Mainwaring RD, Patrick WL, Ibrahimiye AN, et al. Ann Thorac Surg 2018;105:823鈥29.
  4. .鈥 Ibrahimiye AN, Mainwaring RD, Patrick WL, et al. World J Pediatr Congenit Heart Surg 2017;8:203鈥9.
  5. .鈥 Moodley S, Balasubramanian S, Tacy TA, et al. J Am Soc Echocardiogr 2017;30:807鈥14.
  6. .鈥 Zeigler S, Mainwaring RD, Punn R, Petrossian E, Hanley, FL, Ann Thorac Surg 2016 Mar;101(3):1208鈥10.
  7. .鈥 Malhotra SP, Reddy VM, Qiu M, et al. J Thorac Cardiovasc Surg 2011;141:162鈥70.