麻豆果冻传媒

Dane Conrads, now almost 4, was 鈥渄esperately ill鈥� and weighed under five pounds when he received his liver transplant in 2014. Today he is thriving following his second organ transplant in 2017, one of the year鈥檚 most complex kidney transplants performed at Packard Children鈥檚.

For release: March 13, 2018

STANFORD, Calif. 鈥� Dane Conrads was in excellent health when he was born, almost five weeks early, in April 2014 at a hospital in San Francisco. But after a routine circumcision, Dane started bleeding and it wouldn鈥檛 stop.

For Dane鈥檚 parents, A.J. and Ted Conrads, it was an unexpected shock. 鈥淎 blood test showed that his liver enzymes were through the roof, which was a sign that his liver was failing,鈥� recalls A.J.

An ambulance rushed Dane to Lucile Packard Children鈥檚 Hospital Stanford. 鈥淚t was all hands on deck,鈥� says A.J. 鈥淗e was dying quickly from bleeding internally.鈥�

Janene Fuerch, MD, clinical assistant professor of neonatology, was one of the neonatal intensive care unit (NICU) fellows during Dane鈥檚 first several weeks at Packard Children鈥檚. 鈥淗e was in fulminant liver failure, and we knew he was most likely going to die. Neonates in severe liver failure often don鈥檛 survive,鈥� she explains.

Ultimately, it would take two separate organ transplants to save Dane鈥檚 life. He was extremely fortunate to be cared for at Packard Children鈥檚, a longtime leader in pediatric solid-organ transplant. In 2017, Packard Children鈥檚 led the way in pediatric transplant volume and outcomes nationwide, performing 117 pediatric organ transplants, including one of Dane鈥檚. Over the past five years, Packard Children鈥檚 has performed more pediatric liver and kidney transplants than any other U.S. center.

To help him survive his failing liver, Dane鈥檚 doctors stabilized him with several daily blood transfusions and continuous support. Over the next 10 days, rounds of testing revealed that Dane had an enterovirus, a relative of the polio virus.

鈥淗e was really a desperately ill little guy,鈥� says William Benitz, MD, professor of neonatology and Dane鈥檚 attending physician in the NICU. 鈥淗e demonstrated how sick a vulnerable baby can get from what would be a routine, ho-hum, everyday virus for most of us.鈥�

In a premature baby like Dane, enterovirus can cause liver failure, which can lead to brain damage and heart failure. With its wide range of potential symptoms, enterovirus has no available medical cure, so Dane鈥檚 own immune system had to fight the disease.

The next six weeks were a harrowing, daily effort to keep Dane alive and help him grow healthy enough 鈥� and large enough 鈥� to receive a liver transplant. 鈥淲e knew this was a stretch. He would be the smallest transplant the team had ever done,鈥� says Dr. Fuerch. 鈥淏ut he wasn鈥檛 giving up, so we weren鈥檛 going to either.鈥�

The team has a track record of succeeding with unusually challenging transplants.

In 2017, 40 percent of Packard Children鈥檚 liver-transplant recipients weighed less than 40 pounds, making it the national leader in transplanting babies and small children.

The team also had much shorter mean wait times than most centers: 2.2 months, compared to 13.5 months across the nation.

And Dane needed a new liver quickly. Even as his care team worked to stabilize his blood levels every day, Dane鈥檚 failing liver was not doing its job of clearing his blood of protein byproducts like ammonia. This meant he needed continuous hemodialysis, which circulated his blood to clean it externally and return it to his body. 鈥淲e had to balance the risks of bleeding, clotting, and infection and work to optimize his nutrition,鈥� says Cynthia Wong, MD, medical director of chronic dialysis. 鈥淲ith his multiorgan failure, this was the only option to save his life.鈥�

鈥淲hen the interventional radiologist put in a dialysis catheter, it was a tremendous moment of success,鈥� says Waldo Concepcion, MD, chief of pediatric kidney transplantation. 鈥淏eing able to dialyze him so the medical team could stabilize him was very, very critical to his survival.鈥�

In the early hours of May 23, 2014, six-week-old Dane, weighing just under five pounds, received his new liver from a surgical team led by Carlos Esquivel, MD, PhD, chief of the division of transplantation, and Dr. Concepcion.

About six weeks after Dane鈥檚 surgery and his slow, rocky recovery, A.J. and Ted were finally able to pick him up and hold him for the first time since his birth. But soon after his new liver stabilized, Dane鈥檚 kidney failed. Dane now needed peritoneal dialysis to do the work of his kidneys.

On October 8, after six months in the hospital, A.J. and Ted were able to take Dane home, where he would need 11 hours of peritoneal dialysis each day until he could receive a kidney transplant.

Although they were concerned about their son, the family knew of Packard Children鈥檚 outstanding kidney-transplant track record. In 2017, the program performed 46 pediatric kidney transplants, as well as nine transplants in patients aged 18 or over, making it a national leader in kidney-transplant volume. Patients come from across the Western United States and even internationally to benefit from the program鈥檚 expertise.

A.J. hoped to be a living kidney donor for Dane. But Dane needed a perfectly sized kidney, which could only come from a deceased donor. 鈥淭he odds were stacked against Dane both in terms of the complexity of the anticipated surgery and the scarcity of potential donor kidneys,鈥� says Ted.

On April 7, 2017, one day before Dane鈥檚 third birthday, Dr. Concepcion and Amy Gallo, MD, assistant professor of abdominal transplantation surgery, performed Dane鈥檚 pioneering kidney transplant.

鈥淗e was tiny, but we modified and tailored his own kidney vein to be able to drain the new kidney,鈥� says Dr. Concepcion.

鈥淚t was a completely innovative process of doing the kidney transplant using only what the patient had available, which was that one vein.鈥�

It was one of the most complicated of the kidney transplants performed at Packard Children鈥檚 in 2017, though it was not unique: The team also transplanted two other children who had been referred from outside California due to challenging vascular access, as well as a patient who needed a second kidney transplant after becoming immunologically sensitized to the first transplanted organ.

Within 24 hours of his kidney transplant, Dane showed signs of dramatic improvement. He was discharged after 10 days.

Today, Dane loves playing with his little brother, Carter. 鈥淗e鈥檚 just really happy now. He鈥檚 super social and loves his toys and going to music class,鈥� says A.J. 鈥淔inally, after three years, we鈥檙e feeling relaxed 鈥� like, OK, he鈥檚 going to be OK.鈥�

By the numbers: 2017 successes for Packard Children鈥檚 liver and kidney transplant programs

• Packard Children鈥檚 transplanted 46 pediatric kidneys and 43 pediatric livers in 2017, making it the national leader in transplant volume for both organs.
• Nine patients received living-donor kidney transplants.
• Three patients received combined liver/kidney transplants.
• Seven patients received kidneys before starting dialysis, helping maintain their quality of life.
• 12 kidney transplant patients came from out of state, and one from outside the country.
• Six liver transplant recipients had liver tumors.
• 14 liver recipients were transplanted with unusual techniques such as living-donor organs.

Media Contact:

Samantha Beal
sdorman@stanfordchildrens.org
(650) 498-7056