麻豆果冻传媒

Now a first-grader, her lifesaving treatment as a baby led the way for a protocol that has saved the lives of thousands

For Release: March 18, 2015

STANFORD. Calif. - In July 2008, when Isabella Manley was just a few weeks old, she developed rapid, raspy breathing.鈥淪he sounded like Darth Vader,鈥� said her mother, Julie Anna.

鈥淏eing first-time parents, we didn鈥檛 know what to think,鈥� said her dad, Todd. The worried couple took their daughter to the emergency room at a hospital near their Sacramento, Calif., home.

They couldn鈥檛 have guessed what was to come: Isabella would be diagnosed with a tumor so aggressive it would nearly strangle her. And she would become a medical pioneer, among the first to receive a therapy that revolutionized the way these types of tumors are treated.

鈥淭he treatment Isabella received is really a marked advancement over what we had before,鈥� said Kay Chang, MD, the pediatric otolaryngologist who cured Isabella鈥檚 tumor at Lucile Packard Children鈥檚 Hospital Stanford and 麻豆果冻传媒 Children鈥檚 Health. 鈥淭oday, it鈥檚 the standard of care. No one thinks about using other therapies.鈥� Chang is also associate professor of otolaryngology in head and neck surgery at the .

Back in the summer of 2008, Isabella was initially diagnosed with a hemangioma in her airway. The tumor, a mass of blood vessels protruding into her trachea just below her vocal cords, threatened to block the path to her lungs. Hemangiomas often occur on babies鈥� skin, appearing as red spots that are usually harmless. But the dangerous location of Isabella鈥檚 tumor required immediate treatment.

Her doctors in Sacramento tried steroids and laser surgery, then the usual therapies for severe hemangiomas. When those didn鈥檛 work, she was referred to Chang for a second surgery to cut out the tumor and reconstruct her trachea. But shortly after this surgery, when Isabella was about 4 months old, her raspy breathing returned. An MRI scan showed why.

鈥淲e found, to our horror, that this hemangioma was massive, surrounding her entire windpipe and also her heart,鈥� Chang said.

鈥淚t was becoming tangled into every structure in her neck and crawling down into her chest,鈥� said Mai Thy Truong, MD, a pediatric otolaryngologist now with the hospital鈥檚 vascular malformations clinic, which treats children with hemangiomas and other vascular tumors. At the time of Isabella鈥檚 treatment, Truong was completing an otolaryngology fellowship under Chang鈥檚 tutelage and was closely involved in Isabella鈥檚 care.

鈥淲hen I saw that MRI, I was devastated,鈥� said Truong, who is also a clinical assistant professor of otolaryngology at the School of Medicine. The tumor was too extensive for surgery and was still growing. Truong and Chang feared that it would soon block Isabella鈥檚 airway. They were not sure they could save her.

鈥淚t was the worst time for us,鈥� Todd said. 鈥淭he clock was really ticking: her breathing was becoming more labored and the treatments were not working.鈥�

Desperate for answers, Chang recalled a conversation he had heard at a recent medical conference. Some physicians in France had accidentally discovered that a blood pressure medication, propranolol, shrank skin hemangiomas in a few children with high blood pressure who coincidentally had the skin version of the tumor. To Chang鈥檚 knowledge, no one had ever used the drug to treat an airway hemangioma, but Isabella鈥檚 situation was so dire that he wanted to try. The Manleys agreed.

To everyone鈥檚 surprise, Isabella鈥檚 breathing improved in the first 24 hours on the medication. A week later, she received another MRI.

鈥淒r. Chang came and found us and said, 鈥榊ou鈥檝e got to see this; the tumor shrunk in half,鈥欌�� Julie Anna recalled. 鈥淲e were just beside ourselves.鈥�

After enduring such a long struggle to help Isabella breathe, the Manleys cried happy tears. 鈥淚t was one of the best days of our lives,鈥� Todd said.

Chang, meanwhile, couldn鈥檛 stop thinking about what the success meant for other children. 鈥淚 was totally excited,鈥� he said. 鈥淚t鈥檚 rare in medicine that you see something have such a dramatic effect so fast.鈥�

Chang and Truong soon gave a conference presentation at the American Society of Pediatric Otolaryngology about the success of Isabella鈥檚 case, making it the first reported instance of a life-threatening airway hemangioma to be successfully treated with propranolol. Other doctors who had also been inspired by the French team began reporting on their use of the medication, too.

Since Isabella was treated in 2008, thousands of children have received propranolol for serious hemangiomas. A recently published found that more than 99 percent of the tumors responded to the drug, many as quickly as Isabella鈥檚.

In addition to its speed, propranolol is much safer for children than previous hemangioma treatments. For instance, giving steroids can hinder a child鈥檚 growth, and in many cases, steroids only temporarily halt the growth of the tumor. Laser surgery for airway hemangiomas carried the possible side effect of permanent scarring of the vocal cords, which is not a risk with propranolol treatment. Surgeries for large hemangiomas in other locations were often risky and disfiguring, a problem that propranolol has largely solved.

Isabella received propranolol for several months, ending her treatment just before her first birthday. Now a busy first-grader, she loves to read, play soccer, dance and ride her bike.

At a recent checkup, Isabella鈥檚 pediatrician told the Manleys that she had been following reports on the use of propranolol in the medical literature. She told them what a difference the drug has made for so many other kids.

鈥淚t didn鈥檛 hit us until then,鈥� Julie Anna said. 鈥淚sabella really is a trailblazer.鈥�

Authors

Robert Dicks
(650) 497-8364
rdicks@stanfordchildrens.org